high serum levels of rheumatoid factor and anti-phosphatidylserine antibody in patients with ischemic heart disease

background: immunopathological and inflammatory processes play important roles in the initiation and development of ischemic heart disease (ihd). objective: the aim of this study was to evaluate the serum levels of several autoantibodies including rheumatoid factor (rf), anti-nuclear antibodies (ana), anti-small nuclear ribonucleoprotein (anti-sm), anti-phosphatidylserine (anti-ps) and anti-cardiolipin (anti-cl) antibodies in patients with ihd. methods: a total of 120 patients with ihd with acute myocardial infarction (ami; n=60) or unstable angina (ua; n=60) and 60 sex- and age-matched healthy subjects were enrolled in this study. serum samples of participants were tested for the ana, anti-sm, anti-ps and anti-cl antibodies by elisa. serum level of rf was measured by a turbidometric method. results: the mean serum levels of rf and anti-ps antibodies in ami group and ua group were significantly higher than those observed in the control group (p